Alpha/Beta Interferon Protects Adult Mice from Fatal Sindbis Virus Infection and Is an Important Determinant of Cell and Tissue Tropism

Infection of adult 129 Sv/Ev mice with consensus Sindbis virus strain TR339 is subclinical due to an inherent restriction in early virus replication and viremic dissemination. By comparing the pathogenesis of TR339 in 129 Sv/Ev mice and alpha/beta interferon receptor null (IFN-α/βR(−/−)) mice, we ha...

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Bibliographische Detailangaben
Hauptverfasser: Ryman, Kate D., Klimstra, William B., Nguyen, Khuong B., Biron, Christine A., Johnston, Robert E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111838/
https://ncbi.nlm.nih.gov/pubmed/10708454
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