Alpha/Beta Interferon Protects Adult Mice from Fatal Sindbis Virus Infection and Is an Important Determinant of Cell and Tissue Tropism

Infection of adult 129 Sv/Ev mice with consensus Sindbis virus strain TR339 is subclinical due to an inherent restriction in early virus replication and viremic dissemination. By comparing the pathogenesis of TR339 in 129 Sv/Ev mice and alpha/beta interferon receptor null (IFN-α/βR(−/−)) mice, we ha...

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Pubblicato in:	J Virol
Autori principali:	Ryman, Kate D., Klimstra, William B., Nguyen, Khuong B., Biron, Christine A., Johnston, Robert E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111838/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10708454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.7.3366-3378.2000
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