Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors

Adeno-associated virus (AAV) vectors are associated with relatively mild host immune responses in vivo. Although AAV induces very weak innate immune responses, neutralizing antibodies against the vector capsid and transgene still occur. To understand further the basis of the antiviral immune respons...

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Detalhes bibliográficos
Main Authors: Zaiss, Anne K., Cotter, Matthew J., White, Lindsay R., Clark, Sharon A., Wong, Norman C. W., Holers, V. Michael, Bartlett, Jeffrey S., Muruve, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259003/
https://ncbi.nlm.nih.gov/pubmed/18199646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01990-07
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