Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors

Adeno-associated virus (AAV) vectors are associated with relatively mild host immune responses in vivo. Although AAV induces very weak innate immune responses, neutralizing antibodies against the vector capsid and transgene still occur. To understand further the basis of the antiviral immune respons...

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Hlavní autoři: Zaiss, Anne K., Cotter, Matthew J., White, Lindsay R., Clark, Sharon A., Wong, Norman C. W., Holers, V. Michael, Bartlett, Jeffrey S., Muruve, Daniel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259003/
https://ncbi.nlm.nih.gov/pubmed/18199646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01990-07
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