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Conserved Water Molecules Stabilize the Ω-Loop in Class A β-Lactamases

A set of 49 high-resolution (≤2.2 Å) structures of the TEM, SHV, and CTX-M class A β-lactamase families was systematically analyzed to investigate the role of conserved water molecules in the stabilization of the Ω-loop. Overall, 13 water molecules were found to be conserved in at least 45 structure...

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Bibliografiska uppgifter
Huvudupphovsmän: Bös, Fabian, Pleiss, Jürgen
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258531/
https://ncbi.nlm.nih.gov/pubmed/18195065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01035-07
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