Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synt...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Graci, Jason D., Too, Kathleen, Smidansky, Eric D., Edathil, Jocelyn P., Barr, Eric W., Harki, Daniel A., Galarraga, Jessica E., Bollinger, J. Martin, Peterson, Blake R., Loakes, David, Brown, Daniel M., Cameron, Craig E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2008
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258490/
https://ncbi.nlm.nih.gov/pubmed/18180344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01056-07
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller