Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synt...

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Bibliografiske detaljer
Main Authors: Graci, Jason D., Too, Kathleen, Smidansky, Eric D., Edathil, Jocelyn P., Barr, Eric W., Harki, Daniel A., Galarraga, Jessica E., Bollinger, J. Martin, Peterson, Blake R., Loakes, David, Brown, Daniel M., Cameron, Craig E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258490/
https://ncbi.nlm.nih.gov/pubmed/18180344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01056-07
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