Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses. Here we show by using T7 RNA polymerase-mediated production...

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Main Authors: Graci, Jason D., Harki, Daniel A., Korneeva, Victoria S., Edathil, Jocelyn P., Too, Kathleen, Franco, David, Smidansky, Eric D., Paul, Aniko V., Peterson, Blake R., Brown, Daniel M., Loakes, David, Cameron, Craig E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045539/
https://ncbi.nlm.nih.gov/pubmed/17686844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-07
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