Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses. Here we show by using T7 RNA polymerase-mediated production...

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Main Authors: Graci, Jason D., Harki, Daniel A., Korneeva, Victoria S., Edathil, Jocelyn P., Too, Kathleen, Franco, David, Smidansky, Eric D., Paul, Aniko V., Peterson, Blake R., Brown, Daniel M., Loakes, David, Cameron, Craig E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2007
Ábhair:
Vaccines and Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045539/
https://ncbi.nlm.nih.gov/pubmed/17686844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-07
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