Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synt...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Graci, Jason D., Too, Kathleen, Smidansky, Eric D., Edathil, Jocelyn P., Barr, Eric W., Harki, Daniel A., Galarraga, Jessica E., Bollinger, J. Martin, Peterson, Blake R., Loakes, David, Brown, Daniel M., Cameron, Craig E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2008
Aiheet:
Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258490/
https://ncbi.nlm.nih.gov/pubmed/18180344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01056-07
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