Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synt...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Graci, Jason D., Too, Kathleen, Smidansky, Eric D., Edathil, Jocelyn P., Barr, Eric W., Harki, Daniel A., Galarraga, Jessica E., Bollinger, J. Martin, Peterson, Blake R., Loakes, David, Brown, Daniel M., Cameron, Craig E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology (ASM) 2008
Θέματα:
Antiviral Agents
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258490/
https://ncbi.nlm.nih.gov/pubmed/18180344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01056-07
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