Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses. Here we show by using T7 RNA polymerase-mediated production...

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Bibliografiske detaljer
Main Authors: Graci, Jason D., Harki, Daniel A., Korneeva, Victoria S., Edathil, Jocelyn P., Too, Kathleen, Franco, David, Smidansky, Eric D., Paul, Aniko V., Peterson, Blake R., Brown, Daniel M., Loakes, David, Cameron, Craig E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045539/
https://ncbi.nlm.nih.gov/pubmed/17686844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-07
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