Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma

2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies. To facilitate pharmacokinetic evaluation of DMB, we developed an LC-MS assay and quantitated DMB in plasma of rats after an oral dose of 500 mg/kg. After acetonitrile protein precipitation, DMB and dimethylva...

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Hlavní autoři: Parise, Robert A., Beumer, Jan H., Kangani, Cyrous O., Holleran, Julianne L., Eiseman, Julie L., Smith, Nicola F., Covey, Joseph M., Perrine, Susan P., Egorin, Merrill J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254528/
https://ncbi.nlm.nih.gov/pubmed/18155649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2007.12.002
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