Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: distinct effect of progesterone receptor isoforms

There is strong evidence that catechol-O-methyl transferase (COMT) protects breast cells against estrogen-induced cancer by detoxifying catecholestrogens, the carcinogenic estrogen metabolites. COMT gene expression is controlled by two promoters—a proximal promoter (COMTP1) and a distal promoter (CO...

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Bibliographic Details
Main Authors: Salama, Salama A., Jamaluddin, Mohammad, Kumar, Raj, Hassan, Memy H., Al-Hendy, Ayman
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254140/
https://ncbi.nlm.nih.gov/pubmed/17689241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2007.03.049
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