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Temperature-induced reversible conformational change in the first 100 residues of α-synuclein

Natively disordered proteins are a growing class of anomalies to the structure–function paradigm. The natively disordered protein α-synuclein is the primary component of Lewy bodies, the cellular hallmark of Parkinson’s disease. We noticed a dramatic difference in dilute solution (1)H-(15)N Heteronu...

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Detalhes bibliográficos
Main Authors: McNulty, Brian C., Tripathy, Ashutosh, Young, Gregory B., Charlton, Lisa M., Orans, Jillian, Pielak, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249779/
https://ncbi.nlm.nih.gov/pubmed/16452621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051867106
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