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Residue-Level Interrogation of Macromolecular Crowding Effects on Protein Stability

Theory predicts that macromolecular crowding affects protein behavior, but experimental confirmation is scant. Herein, we report the first residue-level interrogation of the effects of macromolecular crowding on protein stability. We observe up to a 100-fold increase in the stability, as measured by...

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Autors principals: Charlton, Lisa M., Barnes, Christopher O., Li, Conggang, Orans, Jillian, Young, Gregory B., Pielak, Gary J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435214/
https://ncbi.nlm.nih.gov/pubmed/18459780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8005995
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