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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Brain glucose uptake/metabolism is impaired in Alzheimer disease (AD). Here, we report that levels of the two major brain glucose transporters (GLUT1 and GLUT3) responsible for glucose uptake into neurons were decreased in AD brain. This decrease correlated to the decrease in O-GlcNAcylation, to the...

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Main Authors: Liu, Ying, Liu, Fei, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247364/
https://ncbi.nlm.nih.gov/pubmed/18174027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.12.035
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