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Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.

We have investigated the effects of localised tumour hyperthermia (LTH; 43.5 degrees C x 30 min) on the acute toxicity and pharmacokinetics of the hypoxic cell sensitizer pimonidazole (Ro 03-8799) in mice. There were three treatment groups: unrestrained controls, sham-treated and LTH treated mice. L...

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Detalhes bibliográficos
Main Authors: Walton, M. I., Bleehen, N. M., Workman, P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247237/
https://ncbi.nlm.nih.gov/pubmed/2736198
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