The effect of systemic hyperthermia on melphalan pharmacokinetics in mice.

The effect of 45 min systemic heating at 41 degrees C on plasma and RIF-1 tumour pharmacokinetics of intraperitoneally administered melphalan (MEL) was studied in C3H mice. This heat dose causes greater potentiation of MEL in tumour than in marrow cells, resulting in a therapeutic gain for the combi...

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Bibliografiska uppgifter
Huvudupphovsmän: Honess, D. J., Donaldson, J., Workman, P., Bleehen, N. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1985
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976822/
https://ncbi.nlm.nih.gov/pubmed/3966973
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