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The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice.

We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001...

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Bibliografiska uppgifter
Huvudupphovsmän: Walton, M. I., Bleehen, N. M., Workman, P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1987
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001726/
https://ncbi.nlm.nih.gov/pubmed/3606940
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