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Dephosphorylation of eIF-2α Mediated by the γ(1)34.5 Protein of Herpes Simplex Virus Type 1 Is Required for Viral Response to Interferon but Is Not Sufficient for Efficient Viral Replication
The γ(1)34.5 protein of herpes simplex virus type 1 (HSV-1) functions to block the shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase (PKR). In this process, the γ(1)34.5 protein recruits cellular protein phosphatase 1 (PP1) to form a high-molecular-weight complex th...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC224583/ https://ncbi.nlm.nih.gov/pubmed/12941928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.18.10154-10161.2003 |
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