Dephosphorylation of eIF2α Mediated by the γ(1)34.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion

The γ(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the α subunit of translation initiation factor 2 (eIF2α). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo...

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Detalhes bibliográficos
Main Authors: Verpooten, Dustin, Feng, Zongdi, Valyi-Nagy, Tibor, Ma, Yijie, Jin, Huali, Yan, Zhipeng, Zhang, Cuizhu, Cao, Youjia, He, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786747/
https://ncbi.nlm.nih.gov/pubmed/19759130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01431-09
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