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Dephosphorylation of eIF2α Mediated by the γ(1)34.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion
The γ(1)34.5 protein, a virulence factor of herpes simplex viruses, redirects protein phosphatase 1 to dephosphorylate the α subunit of translation initiation factor 2 (eIF2α). Additionally, it inhibits the induction of antiviral genes by TANK-binding kinase 1. Nevertheless, its precise role in vivo...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786747/ https://ncbi.nlm.nih.gov/pubmed/19759130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01431-09 |
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