Podocytes use FcRn to clear IgG from the glomerular basement membrane

The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here, we provide evidence that an active transport mechanism exists...

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Autors principals: Akilesh, Shreeram, Huber, Tobias B., Wu, Hui, Wang, Gary, Hartleben, Björn, Kopp, Jeffrey B., Miner, Jeffrey H., Roopenian, Derry C., Unanue, Emil R., Shaw, Andrey S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242706/
https://ncbi.nlm.nih.gov/pubmed/18198272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711515105
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