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Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase

Among the many parameters that have been proposed to promote amyloid fibril formation is the π-stacking of aromatic residues. We have studied the amyloid aggregation of several mutants of human muscle acylphosphatase in which an aromatic residue was substituted with a non-aromatic one. The aggregati...

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Main Authors: Bemporad, Francesco, Taddei, Niccolò, Stefani, Massimo, Chiti, Fabrizio
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242477/
https://ncbi.nlm.nih.gov/pubmed/16600970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051915806
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