Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies

The acylphosphatase from Sulfolobus solfataricus (Sso AcP) is a globular protein able to aggregate in vitro from a native-like conformational ensemble without the need for a transition across the major unfolding energy barrier. This process leads to the formation of assemblies in which the protein r...

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Vydáno v:Biophys J
Hlavní autoři: Elia, Francesco, Cantini, Francesca, Chiti, Fabrizio, Dobson, Christopher Martin, Bemporad, Francesco
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479110/
https://ncbi.nlm.nih.gov/pubmed/28636911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.05.011
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