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Prevention of amyloid-like aggregation as a driving force of protein evolution

Uncontrolled protein aggregation is a constant challenge in all compartments of living organisms. The failure of a peptide or protein to remain soluble often results in pathology. So far, more than 40 human diseases have been associated with the formation of extracellular fibrillar aggregates—known...

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Detalhes bibliográficos
Main Authors: Monsellier, Elodie, Chiti, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978086/
https://ncbi.nlm.nih.gov/pubmed/17668004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401034
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