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The Distribution of Residues in a Polypeptide Sequence Is a Determinant of Aggregation Optimized by Evolution
It has been shown that the propensity of a protein to form amyloid-like fibrils can be predicted with high accuracy from the knowledge of its amino acid sequence. It has also been suggested, however, that some regions of the sequences are more important than others in determining the aggregation pro...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2098718/ https://ncbi.nlm.nih.gov/pubmed/17766358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.111336 |
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