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The Distribution of Residues in a Polypeptide Sequence Is a Determinant of Aggregation Optimized by Evolution

It has been shown that the propensity of a protein to form amyloid-like fibrils can be predicted with high accuracy from the knowledge of its amino acid sequence. It has also been suggested, however, that some regions of the sequences are more important than others in determining the aggregation pro...

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מידע ביבליוגרפי
Main Authors: Monsellier, Elodie, Ramazzotti, Matteo, de Laureto, Patrizia Polverino, Tartaglia, Gian-Gaetano, Taddei, Niccolò, Fontana, Angelo, Vendruscolo, Michele, Chiti, Fabrizio
פורמט: Artigo
שפה:Inglês
יצא לאור: The Biophysical Society 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2098718/
https://ncbi.nlm.nih.gov/pubmed/17766358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.111336
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