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Characterizing Intermolecular Interactions That Initiate Native-Like Protein Aggregation

Folded proteins can access aggregation-prone states without the need for transitions that cross the energy barriers for unfolding. In this study we characterized the initial steps of aggregation from a native-like state of the acylphosphatase from Sulfolobus solfataricus (Sso AcP). Using computer si...

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Bibliografiske detaljer
Main Authors: Bemporad, Francesco, De Simone, Alfonso, Chiti, Fabrizio, Dobson, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368139/
https://ncbi.nlm.nih.gov/pubmed/22713575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.057
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