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New algorithms and an in silico benchmark for computational enzyme design

The creation of novel enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Here we describe two new algorithms for enzyme design that employ hashing techniques to allow searching through large numbers of protein scaffolds for optimal cata...

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Detalhes bibliográficos
Main Authors: Zanghellini, Alexandre, Jiang, Lin, Wollacott, Andrew M., Cheng, Gong, Meiler, Jens, Althoff, Eric A., Röthlisberger, Daniela, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242439/
https://ncbi.nlm.nih.gov/pubmed/17132862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062353106
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