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Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer
Dmp1 (Dmtf1) is activated by oncogenic Ras-Raf-signaling and induces cell cycle arrest in an Arf, p53-dependent fashion. The survival of K-ras(LA) mice was shortened by ~15 weeks in both Dmp1(+/−) and Dmp1(−/−) backgrounds, the lung tumors of which showed significantly decreased frequency of p53 mut...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2239345/ https://ncbi.nlm.nih.gov/pubmed/17936562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.08.034 |
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