Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer

Dmp1 (Dmtf1) is activated by oncogenic Ras-Raf-signaling and induces cell cycle arrest in an Arf, p53-dependent fashion. The survival of K-ras(LA) mice was shortened by ~15 weeks in both Dmp1(+/−) and Dmp1(−/−) backgrounds, the lung tumors of which showed significantly decreased frequency of p53 mut...

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Detalhes bibliográficos
Main Authors: Mallakin, Ali, Sugiyama, Takayuki, Taneja, Pankaj, Matise, Lauren A., Frazier, Donna P., Choudhary, Mayur, Hawkins, Gregory A., D'Agostino, Ralph B., Willingham, Mark C., Inoue, Kazushi
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2239345/
https://ncbi.nlm.nih.gov/pubmed/17936562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.08.034
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