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Critical roles of DMP1 in HER2/neu-Arf-p53 signaling and breast cancer development

HER2 overexpression stimulates cell growth in p53-mutated cells while it inhibits cell proliferation in those with wild-type p53, but the molecular mechanism is unknown. The Dmp1 promoter was activated by HER2/neu through the PI3K-Akt-NF-κB pathway, which in turn stimulated Arf transcription. Bindin...

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Detalhes bibliográficos
Main Authors: Taneja, Pankaj, Maglic, Dejan, Kai, Fumitake, Sugiyama, Takayuki, Kendig, Robert D., Frazier, Donna P., Willingham, Mark C., Inoue, Kazushi
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073839/
https://ncbi.nlm.nih.gov/pubmed/21062982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0159
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