Dmp1α Inhibits HER2/neu-Induced Mammary Tumorigenesis

Our recent study shows a pivotal role of Dmp1 in quenching hyperproliferative signals from HER2 to the Arf-p53 pathway as a safety mechanism to prevent breast carcinogenesis. To directly demonstrate the role of Dmp1 in preventing HER2/neu-driven oncogenic transformation, we established Flag-Dmp1α tr...

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Bibliographic Details
Main Authors: Fry, Elizabeth A., Taneja, Pankaj, Maglic, Dejan, Zhu, Sinan, Sui, Guangchao, Inoue, Kazushi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812138/
https://ncbi.nlm.nih.gov/pubmed/24205004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077870
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