Cooperation between Dmp1 Loss and Cyclin D1 Overexpression in Breast Cancer

Cyclin D1 is a component of the core cell-cycle machinery and is frequently overexpressed in breast cancer. It physically interacts with the tumor suppressor Dmp1 that attenuates the oncogenic signals from Ras and HER2 by inducing Arf/p53-dependent cell-cycle arrest. Currently, the biological signif...

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Detalhes bibliográficos
Main Authors: Zhu, Sinan, Mott, Ryan T., Fry, Elizabeth A., Taneja, Pankaj, Kulik, George, Sui, Guangchao, Inoue, Kazushi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791682/
https://ncbi.nlm.nih.gov/pubmed/23938323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.06.027
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