Molecular switch for CLC-K Cl(−) channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands

ClC-Ka and ClC-Kb Cl(−) channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, we followed a rational chemical strategy, accompani...

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Main Authors: Liantonio, Antonella, Picollo, Alessandra, Carbonara, Giuseppe, Fracchiolla, Giuseppe, Tortorella, Paolo, Loiodice, Fulvio, Laghezza, Antonio, Babini, Elena, Zifarelli, Giovanni, Pusch, Michael, Camerino, Diana Conte
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234145/
https://ncbi.nlm.nih.gov/pubmed/18216243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708977105
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