I–J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes

CLC-K chloride channels and their subunit, barttin, are crucial for renal NaCl reabsorption and for inner ear endolymph production. Mutations in CLC-Kb and barttin cause Bartter syndrome. Here, we identified two adjacent residues, F256 and N257, that when mutated hugely alter in Xenopus oocytes CLC-...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Gradogna, Antonella, Imbrici, Paola, Zifarelli, Giovanni, Liantonio, Antonella, Camerino, Diana Conte, Pusch, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Pub. Co 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331650/
https://ncbi.nlm.nih.gov/pubmed/25073071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2014.07.021
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