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Molecular switch for CLC-K Cl(−) channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands
ClC-Ka and ClC-Kb Cl(−) channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, we followed a rational chemical strategy, accompani...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234145/ https://ncbi.nlm.nih.gov/pubmed/18216243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708977105 |
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