Molecular switch for CLC-K Cl(−) channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands

ClC-Ka and ClC-Kb Cl(−) channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, we followed a rational chemical strategy, accompani...

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Détails bibliographiques
Auteurs principaux: Liantonio, Antonella, Picollo, Alessandra, Carbonara, Giuseppe, Fracchiolla, Giuseppe, Tortorella, Paolo, Loiodice, Fulvio, Laghezza, Antonio, Babini, Elena, Zifarelli, Giovanni, Pusch, Michael, Camerino, Diana Conte
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234145/
https://ncbi.nlm.nih.gov/pubmed/18216243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708977105
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