Molecular switch for CLC-K Cl(−) channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands

ClC-Ka and ClC-Kb Cl(−) channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, we followed a rational chemical strategy, accompani...

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Xehetasun bibliografikoak
Egile Nagusiak: Liantonio, Antonella, Picollo, Alessandra, Carbonara, Giuseppe, Fracchiolla, Giuseppe, Tortorella, Paolo, Loiodice, Fulvio, Laghezza, Antonio, Babini, Elena, Zifarelli, Giovanni, Pusch, Michael, Camerino, Diana Conte
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234145/
https://ncbi.nlm.nih.gov/pubmed/18216243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708977105
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