Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels

BACKGROUND AND PURPOSE: ClC-K kidney Cl(−) channels are important for renal and inner ear transepithelial Cl(−) transport, and are potentially interesting pharmacological targets. They are modulated by niflumic acid (NFA), a non-steroidal anti-inflammatory drug, in a biphasic way: NFA activates ClC-...

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Detalhes bibliográficos
Main Authors: Zifarelli, G, Liantonio, A, Gradogna, A, Picollo, A, Gramegna, G, De Bellis, M, Murgia, AR, Babini, E, Conte Camerino, D, Pusch, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936838/
https://ncbi.nlm.nih.gov/pubmed/20649569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00822.x
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