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Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

Alterations in cerebrovascular regulation related to vascular oxidative stress have been implicated in the mechanisms of Alzheimer's disease (AD), but their role in the amyloid deposition and cognitive impairment associated with AD remains unclear. We used mice overexpressing the Swedish mutati...

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Main Authors: Park, Laibaik, Zhou, Ping, Pitstick, Rose, Capone, Carmen, Anrather, Josef, Norris, Erin H., Younkin, Linda, Younkin, Steven, Carlson, George, McEwen, Bruce S., Iadecola, Costantino
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234141/
https://ncbi.nlm.nih.gov/pubmed/18202172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711568105
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