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Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner

We investigated the effect of protein kinase A (PKA) on passive force in skinned cardiac tissues that express different isoforms of titin, i.e., stiff (N2B) and more compliant (N2BA) titins, at different levels. We used rat ventricular (RV), bovine left ventricular (BLV), and bovine left atrial (BLA...

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Autori principali: Fukuda, Norio, Wu, Yiming, Nair, Preetha, Granzier, Henk L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234012/
https://ncbi.nlm.nih.gov/pubmed/15738048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409177
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