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Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner

We investigated the effect of protein kinase A (PKA) on passive force in skinned cardiac tissues that express different isoforms of titin, i.e., stiff (N2B) and more compliant (N2BA) titins, at different levels. We used rat ventricular (RV), bovine left ventricular (BLV), and bovine left atrial (BLA...

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Detalhes bibliográficos
Main Authors: Fukuda, Norio, Wu, Yiming, Nair, Preetha, Granzier, Henk L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234012/
https://ncbi.nlm.nih.gov/pubmed/15738048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409177
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