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Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production.
BACKGROUND: Amyloid beta-protein (A beta), the major constituent of amyloid deposits found in Alzheimer's disease, is derived from the beta-amyloid precursor protein (beta PP). Constitutive proteolysis by alpha-secretase and secretion of soluble beta PP (beta PPs) are stimulated by protein kina...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Feinstein Institute for Medical Research
1997
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2230050/ https://ncbi.nlm.nih.gov/pubmed/9100226 |
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