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Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production.

BACKGROUND: Amyloid beta-protein (A beta), the major constituent of amyloid deposits found in Alzheimer's disease, is derived from the beta-amyloid precursor protein (beta PP). Constitutive proteolysis by alpha-secretase and secretion of soluble beta PP (beta PPs) are stimulated by protein kina...

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Detalhes bibliográficos
Autor principal: Koo, E. H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Feinstein Institute for Medical Research 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230050/
https://ncbi.nlm.nih.gov/pubmed/9100226
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