Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production.

BACKGROUND: Amyloid beta-protein (A beta), the major constituent of amyloid deposits found in Alzheimer's disease, is derived from the beta-amyloid precursor protein (beta PP). Constitutive proteolysis by alpha-secretase and secretion of soluble beta PP (beta PPs) are stimulated by protein kina...

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Bibliographic Details
Main Author: Koo, E. H.
Format: Artigo
Language:Inglês
Published: The Feinstein Institute for Medical Research 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2230050/
https://ncbi.nlm.nih.gov/pubmed/9100226
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