Structural Determinants of Pip(2) Regulation of Inward Rectifier K(ATP) Channels

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates K(ATP) and other inward rectifier (Kir) channels. To determine residues important for PIP(2) regulation, we have systematically mutated each positive charge in the COOH terminus of Kir6.2 to alanine. The effects of these mutations on channel f...

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Detaylı Bibliyografya
Asıl Yazarlar: Shyng, Show-Ling, Cukras, Catherine A., Harwood, Jane, Nichols, Colin G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2000
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229479/
https://ncbi.nlm.nih.gov/pubmed/11055989
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