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Structural Determinants of Pip(2) Regulation of Inward Rectifier K(ATP) Channels

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates K(ATP) and other inward rectifier (Kir) channels. To determine residues important for PIP(2) regulation, we have systematically mutated each positive charge in the COOH terminus of Kir6.2 to alanine. The effects of these mutations on channel f...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shyng, Show-Ling, Cukras, Catherine A., Harwood, Jane, Nichols, Colin G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229479/
https://ncbi.nlm.nih.gov/pubmed/11055989
Tagiau: Ychwanegu Tag
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