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A Structural Determinant for the Control of PIP(2) Sensitivity in G Protein-gated Inward Rectifier K(+) Channels
Inward rectifier K(+) (Kir) channels are activated by phosphatidylinositol-(4,5)-bisphosphate (PIP(2)), but G protein-gated Kir (K(G)) channels further require either G protein βγ subunits (Gβγ) or intracellular Na(+) for their activation. To reveal the mechanism(s) underlying this regulation, we co...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992284/ https://ncbi.nlm.nih.gov/pubmed/20880843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161703 |
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