A Structural Determinant for the Control of PIP(2) Sensitivity in G Protein-gated Inward Rectifier K(+) Channels

Inward rectifier K(+) (Kir) channels are activated by phosphatidylinositol-(4,5)-bisphosphate (PIP(2)), but G protein-gated Kir (K(G)) channels further require either G protein βγ subunits (Gβγ) or intracellular Na(+) for their activation. To reveal the mechanism(s) underlying this regulation, we co...

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Bibliografiske detaljer
Main Authors: Inanobe, Atsushi, Nakagawa, Atsushi, Matsuura, Takanori, Kurachi, Yoshihisa
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992284/
https://ncbi.nlm.nih.gov/pubmed/20880843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.161703
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