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Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein

The NS5A protein of hepatitis C virus (HCV) plays an important but undefined role in viral RNA replication. NS5A has been proposed to be a three-domain protein, and the crystal structure of the well-conserved amino-terminal domain I has been determined. The remaining two domains of NS5A, designated...

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Autori principali: Tellinghuisen, Timothy L., Foss, Katie L., Treadaway, Jason C., Rice, Charles M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224455/
https://ncbi.nlm.nih.gov/pubmed/18032500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00328-07
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