Conserved GXXXG- and S/T-Like Motifs in the Transmembrane Domains of NS4B Protein Are Required for Hepatitis C Virus Replication

Hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is an integral membrane protein, which plays an important role in the organization and function of the HCV replication complex (RC). Although much is understood about its amphipathic N-terminal and C-terminal domains, we know very little about...

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Main Authors: Han, Qingxia, Aligo, Jason, Manna, David, Belton, Kerry, Chintapalli, Sree V., Hong, Yoojin, Patterson, Randen L., van Rossum, Damian B., Konan, Kouacou V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126491/
https://ncbi.nlm.nih.gov/pubmed/21507970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02298-10
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