Conserved GXXXG- and S/T-Like Motifs in the Transmembrane Domains of NS4B Protein Are Required for Hepatitis C Virus Replication

Hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is an integral membrane protein, which plays an important role in the organization and function of the HCV replication complex (RC). Although much is understood about its amphipathic N-terminal and C-terminal domains, we know very little about...

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Autori principali: Han, Qingxia, Aligo, Jason, Manna, David, Belton, Kerry, Chintapalli, Sree V., Hong, Yoojin, Patterson, Randen L., van Rossum, Damian B., Konan, Kouacou V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126491/
https://ncbi.nlm.nih.gov/pubmed/21507970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02298-10
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