Hepatitis C Virus RNA Replication and Virus Particle Assembly Require Specific Dimerization of the NS4A Protein Transmembrane Domain

Hepatitis C virus (HCV) NS4A is a single-pass transmembrane (TM) protein essential for viral replication and particle assembly. The sequence of the NS4A TM domain is highly conserved, suggesting that it may be important for protein-protein interactions. To test this hypothesis, we measured the poten...

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Detalhes bibliográficos
Main Authors: Kohlway, Andrew, Pirakitikulr, Nathan, Barrera, Francisco N., Potapova, Olga, Engelman, Donald M., Pyle, Anna M., Lindenbach, Brett D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911751/
https://ncbi.nlm.nih.gov/pubmed/24173222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02052-13
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