The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication

Hepatitis C virus (HCV) nonstructural protein 4A (NS4A) is only 54 amino acids (aa) in length, yet it is a key regulator of the essential serine protease and RNA helicase activities of the NS3-4A complex, as well as a determinant of NS5A phosphorylation. Here we examine the structure and function of...

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Päätekijät: Lindenbach, Brett D., Prágai, Béla M., Montserret, Roland, Beran, Rudolf K. F., Pyle, Anna M., Penin, François, Rice, Charles M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2007
Aiheet:
Genome Replication and Regulation of Viral Gene Expression
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951449/
https://ncbi.nlm.nih.gov/pubmed/17581983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00937-07
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